Have to agree with enysse, (he beat me to it), the major factor that would determine the purchase of one rifle caliber over the other, for use worldwide, would be ammo availability. The 375 H&H is a fantastic caliber and has more than proven itself for a long time, and the factory loaded ammo is everywhere the big stuff is located. I only have book knowledge of the 375 Ruger, but cartridge performance duplicates the H&H, so in my opinion, it's like reinventing the wheel, is the shorter stroke really gonna make that much damn difference for the guy that practices with his rifle??? I highly doubt it. 375 H&H all the way. good luck no matter which you decide on, contrary to a few of the post here, my new Ruger is a fantastic design and functions flawlessly, I love the rifle. The CZ 550 is a well built and working tool for the field, neither much to look at, but your quarry won't give a crap what your gun looks like, he's just going to know that it hurt.