Shot a cape buffalo last week at 30 yds broadside slightly quartering. Shot on the front of the front leg a third of the way up with .375 H&H Barnes 300g TSX. Went 25 yds. Hit both both lungs just above the heart. Very effective. Low lung shot appeared to work well in this case but it may have been the veins/arteries from the heart that dropped it quickly. Not conclusive on high vs low lung shot... Bullet ended up under the hide on the off shoulder.