I have a double rifle regulated with Hornady ammunition, and Hornady is the only major manufacturer who makes ammunition for the .450-400 NE 3". I experimented with several handloads before my hunt, but in the end just loaded their new 400 grain DGX Bonded load for the first shot at buffalo. The buffalo I shot was facing me, slightly angling to my right. Bullet entered the chest missing the big humerus bone, passed just over the heart through at least one lung and was lost somewhere in the rumen. There was a very obvious reaction to the shot, and he couldn't use his right front leg, but we will never know if it would have been a quickly fatal shot because the buffalo was standing 40 meters from Namibia's border with Botswana and if it made it that far it would be lost. So I not only put a solid into him from behind as he turned and ran, but so did my PH and his assistant. The entry wound from the DGX bonded bullet inside the chest cavity showed proper expansion and no fragmentation. That's all I can tell you. The other hole showing in the picture is from the North Fork cup point solid handload I shot from behind. It penetrated well, and stuck in the rear rib cage.
