Matt,
I'm a great fan of Barnes TSX or TTSX. If you can get them to group in your rifle, then they will get the job done. None of my hunters have ever been let down by Nosler Accubonds either.
Also, my personal opinion is do not go heavier than the 168gr'ers, especially in the Eastern Cape. My .308 is loaded with 130gr monolithic solids, and they flatten everything on the plains game list.
Its just my personal opinion, but I would stay away from the 180gr bullets. I don't believe that the .308Win has the powder capacity to give the cartridge enough legs.
Although they punch well above their weight in the "toughness" category, the .308 will smoke a Blue Wildebeest. Shot placement is critical on these beasts.
Best Regards,
Marius