The answer is YES! Many cape buff, water buff, bison, big bears, etc have been taken with the .405 WCF with the proper bullets. I have taken all those with my .405 and you should be able to find my 2012 cape buff post on this site.
On the non dangerous game I used 300 grain bullets and prefer the Northfork selection as they address all needs.
For the cape buff, I used 400 grain Woodleighs at 2080 fps (the regulation velocity for a friends 450-400 double) and it did the job nicely.
Hi Crs,
Good information, thanks for posting it.
I am in agreement with you that a 400 grain bullet in this cartridge should put it into a different category.
If I had a .405, as long as the chamber pressure is safe, then I might be interested in trying 400 grainers in it.
Not sure my wimpy shoulder would appreciate it from a Model 95 lever action though (light overall weight rifle and a lot of drop in the stock shape) but I would try it, again if I had one, which I sadly do not.
The regular 300 grainers at about 2200 fps are pretty sporting in recoil but not brutal, from what I remember back when I had fired one.
I was thinking of that factory standard 300 gr load when I responded, "something else" to the OP's question, due simply to the low sectional density of a 300 grain bullet in .41 caliber.
On a DVD, I saw that the famous author Craig Boddington had Hornady load up some 400 grain solids for his daughter to use in her Ruger No1 single shot on a buffalo (Zimbabwe?)
And it worked well.
That ammunition is not sold to the general public though.
As you have done, handloading is the only way to get it.
However, for my safari dollar, if I wanted to bring an approximately .40 caliber Ruger single shot for buffalo, I would just get their .450/400 caliber in the first place.
Cheers,
Velo Dog.