I personally don't think it has enough mustard to be a stopping rifle.
If you consider a load of:
400 gr @ 2150fps (which is arguably a bit faster thank normal).
You get figures that look like this:
KE: 4100 foot lbs
Momentum: 122
Taylor KO: 50
When you think of common rifles used by PH's, it tends to be things like:
500 NE, or 470 NE In doubles; or
458 lott, 505 gibbs in bolt guns.
Of those, the weakest is the 470 nitro, and its figures are around 25% more across the board.
KE: 5100 ft lbs
Momentum: 153
Taylor KO: 72
So mathematically the choices being made by PH's tend to point to a 450/400 being a bit anemic for stopping. BUT... I do think they make a fabulous cal for visiting hunters. They have great figures compared to their recoil, and make sweet handling rifles. It just looks like you need a little more to address a charge.