For dangerous game it would be marginal at best. This round is essentially a 45-70. A mid-forty's sweet spot when used on dangerous game begins with 400 gr bullets. Most data that I have seen from guide guns and the like show that weight leaving the barrel at 1900 fps and hitting game at 1700 or so at 100 meters with the 450 Marlin. That is a prescription for a wounded buff on anything but a perfect presentation. I personally haven't seen one of those yet.
I wouldn't think about trying to brain an elephant with those ballistics.
Set up with a quality scope, it would work fine on a leopard, but not make the energy minimums in some places. I am sure it would also kill a lion, though I personally would want something a bit more versatile and harder hitting.
It would be fine for PG assuming you are willing to limit your range.
It would also be a fine bear rifle with the same range limitations. However, my last two black bears were both killed just inside 200 yards. At that range, you would firing with a howitzer's trajectory, and hitting them with little better than pistol velocity.
Why not a 9.3 on that action? One hardly sees them on every gun rack, and it is a far more versatile cartridge.