I have a few guys tell me not house the Barnes TSX 300 gr 375 bullet for my upcoming lion hunt , because they say the bullet won't open up on a lion, so I decided to do a little field research today. I went out and called in a coyote to 100 yards and shot him in the throat just below the jaw as he was looking at me in the sagebrush , all I could see was his head. I am now convinced that the 300 gr Barnes TSX is the perfect bullet for lion. Nearly a 4 inch hole in the back of his neck.