The influence of temperature and altitude on ballistics is a complex topic with many uncertainty , and that is being discussed very controversially. The air resistance that changes according to temperature and altitude plays a role , but both factors have also a great influence on the burning rate of the powder with great pressure fluctuations when firing the cartridge. All is difficult because there are also differences among the cartridges of different calibers. If there are moreover shots at extreme angles , everything becomes even more complicated.
If you want to hunt in the extreme heat or cold , or in very high mountains , you have to test your rifle on site. I would never experiment with an DR at higher altitudes and temperature fluctuations. One already have enough accuracy problems with these objects at the same height and the same temperature. If it gets for hunting to the extreme , in the arctic or in the very high mountains , it's better you take a bolt action rifle.