Used to be a big no-no in the old days of wood stocks that took the opportunity to warp, bend, swell, etc. etc., and when torque accuracy on assembly screws was measured by how loud the grunt was when tightening them, but it is just as reliable as assembling and disassembling a Blaser nowadays with the synthetic stocks that have aluminum full length bedding blocks and pillars.
I have not taken rifles to Africa like that yet, but I have been doing a lot of measuring to do it, working to fit 2 Mark V barreled and scoped actions (.257 & .340 Wby), 1 Bell & Carlson stock, and 1 Kreighoff .470 double into a Pelican iM3100 Storm Long Case (39.80" x 16.50" x 6.70"), and I have proofed the concept by taking the steel out of the stock on both Mark V, reassembled them alternatively on a single stock using a Fat Wrench torque limiter to get the exact same screws and receivers tension, and both barreled & scoped actions swapped in the same common stock have kept zero at the 100 yd range. Very promising...
In my case, the 26" Wby barrels and almost 8" long Mark V actions still require a fairly long rifle case (40" external, 36" internal), but it is noticeably shorter than the 53" Pelican 1750 I am currently using, and I 'think' (I still need to final test it in a mock cardboard case) that I will be able to fit 1 stock, 2 barreled & scoped actions and 1 double rifle in it. Worst case scenario, the scopes are mounted on Talley bases with Talley rings that are detachable and have a reputation for being reliably repeatable, but I have not tested that yet.