Hi 700 xcr - In my experience, when considering Africa's heavyweights, moving up in bullet weight from 300 to 350 grain really shifts the .375 H&H up a gear. If you do the math, it is easy to understand why this bullet weight just seems to 'hit harder'.
When comparing a 300 grainer at 2500 to a 350 at 2300 the heavier option gives you more momentum and a better KO value for almost identical ME.
When designed correctly heavier for caliber bullets should expand to a larger final diameter than lighter ones of the same type. Permanent wound channel size, with expanding type bullets is reliably three times a bullets final expanded diameter. So a bullet which expands to .5 inch gives a 1.5 inch diameter hole or PWC (permanent wound channel). One that expands to 1 inch leaves a 3 inch hole. Logically, the bigger the hole though the heart/lung area, the more rapidly effective the shot will be. Granted, expanding to a larger final diameter does put 'the brakes on' more - but this seems to be adequately compensated for by such bullets better momentum value - the secret to bullet penetration. Ideally an expanding type bullet should be recovered under the skin on the opposite side of a side-on animal and this seems to happen with the heavyweights, even on buffalo - with the added advantage being a nice and big PWC.
I have no experience with these bullets in the .375 Ruger but I see no reason why they will not work as well as they do in the .375 H&H assuming the Ruger also has a 1:12 twist. Heavy for caliber bullets are usually longer and because of this they need to spin faster to stabilize. My experience is that even 380 Rhino's will stabilize in a 1:12 twist. 2300 fps is plenty fast enough for 350's - and I would not recommend any more than this for the Woodleighs.
You may also like to look at North Fork's 350 grain .375 offerings. These bullets are rapidly gaining an excellent African reputation, and they come in SP, CNS and FNS configuration which covers all the options.