When I built my .300 Wby in 2009, the first hunting bullet that I tried in it were the Barnes 168 gr TSXs. My first hunt with them was in Texas for Exotics, a blackbuck, an Aoudad, and a Scimitar horn oryx were all one shot bang flops.
I then took that rifle with those bullets on a South African hunt where again they made one shot DRT kills on a warthog, a Sable antelope, a white blesbok,a baboon at 310 yds, and a Klipspringer at 290 yds.
Then back at home, I used my .300 Wby with a 168 gr TSX for a 5x5 bull elk. He ran 3 steps after the shot and fell dead.
Just before my New Zealand hunt in 2014 I decided to try the 168 gr TTSX bullets in my .300 Wby. They were just slightly more accurate, so I used them on that hunt. My first 310 yd shot at a fallow deer didn't immediately drop him so I shoot him again --- my first 2 shot kill with my .300 Wby. I went on to make one shot DRT kills on a Red Stag, a Himalayan tahr, and an Arapawa ram.
Back home again, I again used my .300 Wby with a 168 gr TTSX bullet for another one shot DRT kill on another 5x5 bull elk.
A couple of years later I went on my first Mozambique hunt and my .300 Wby and 168 gr TTSX bullets again made one shot kills on several animals: a warthog, a baboon, a meat sable antelope, and a trophy sable bull that wouldn't let our own Super Moderator Brickburn get close enough to him with his sharp sticks, so on the last day of his hunt I offered Wayne my .300 Wby and a 168 gr TTSX bullet put a big smile on his face.
On the second night of that hunt, a 168 gr TTSX killed my Leopard, but he was able to run 18 paces from where I shot him before he died.
On my first hunt in Mozambique we saw but I couldn't get a shot at a monster Sable bull, so I went back after him the next year. The hunting concession that we hunted on was 690,000 acres and we couldn't find the monster Sable that we saw the year before, but I did use my .300 Wby with 168 gr TTSX bullets to make one shot DRT kills on a warthog and grey Duiker for camp meat, and for a young sable bull that we found with one of his front legs broken in a poacher's gin trap.
And finally, on the last day of that hunt I got my 41" trophy Sable bull.