I have not shot a buff with .375 Ruger. I have shot in CMP/military high power matches. I have hunted a couple of decades. I have shot:
- a Giraffe bull (about twice the size/weight of the buffalo) at 100 yards - bullet stopped an inch past the heart, 2nd round went into the shoulder/did not penetrate the lung cavity as adrenaline had kicked in for his 40 yard sprint to the ground - a third round finished him
- a Zebra stallion at 110 yards - 1st round dropped him (perfectly on the chevron), he got up and 2nd round broke both shoulders, 3rd round at 2 yards finished him
- Oryx at 50 yards - one shot, 100 yard tracking
- Kudu at 50 yards - one shot, no tracking
- Gemsbok - 253 lazered - one shot, dropped in tracks, 2nd shot to finish when we got there
- Blue Wildebeest - 70 yards - one shot - 400 yards of tracking later we found blood/lung tissue 5 yards from where he fell over - perfect shot through the boiler room
- Impala - 70 yards - one shot drop in tracks
- Baboon - 200 yards running away - one shot
- Baboon - 35 yards sitting - one shot
All of these were Barnes 270gr TSX - some Buffalo Bore, some my reloads. My 20" barreled Ruger Alaskan is a "fast" rifle, firing a QuickLoad recipe that is supposed to make 2611 FPS at 2714 FPS
When I get to go back for a buff, I plan to use a .495 A-Square with a 570 grain projo. If I was using the .375 Ruger, I would go for 300gr projos (TSX followed by solids). I intend to play with 350 grain projos, but have not gotten there yet.
I can reload .375 Ruger with Hornady 270gr SP-RP for $3.13 per round (the first time - the other 9 uses of the cartridge case are tallied at $1.53, or averaged across 10 firings, $1.69 per round). I just looked up .375 Ruger 270gr on AmmoSeek and it is selling for #3.43/round. The Hornady 270gr SP-RP is fine for deer here in the US, but I would rather go to Africa with the Barnes 270gr TSX, or the 300gr.
YMMV, however, I think worrying about the muzzle velocity is not meaningful. As long as you are in the window for your bullet of where it will open up effectively - not driving it too fast, as in a Weatherby cartridge - not so slow that it won't open up - then get the turret dial for your Leupold scope and just practice more. The Blesbock was my toughest shot - off a tree limb, as I could not get steady enough off the sticks - I dialed it to 250 and hit perfectly. The velocity didn't matter because the dial compensated for it. 250 yards barely began to factor in trajectory anyway. Will you take a shot at a buffalo at 400 yards? That is where I see .30-06 like trajectories (like the .375 Ruger) begin to diverge noticeably due to velocity differences - and this is where the spitzer boat tail starts to beat the flat base bullets.
I selected my loading with the 1st priority being below 62,000 PSI in Quickload, then took the 2nd harmonic sweet spot. I gave up the blazing fast FPS and the other 3,000 PSI the steel will take as a safety margin for Murphy. The 2714 FPS has killed all I have hit with it very dead even if I added additional rounds for finishing the animal to spare it misery.
The Hornady box label ballistics are fired from a 24" barrel if I recall correctly, so factor that into the equation. You will need "Minute of Cape Buffalo" accuracy - pretty easy to get at 100 yards. Pick a load you can get, that shoots well in your rifle, and practice perfectly a shit ton!
Hope some of this drivel helps you weigh things out.