Of course.For CEB solids .375 (.19) , .458 (.20), and .510 (.20) solids more ore less have the same BC. From Chuck Hawks web site the SD are below.
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Seems like the .375 is like a very small ash tray compared to the bigger bores.
In all seriousness though, anything over .300 is good for penetrating thick-skinned African DG. At the distance most shoot DG (< 50 meters) BC doesn't really matter much.
It was the .500 shooting 350 ESP’s that caught my attention. Would they soar if they are deflected edge on?