The new ruger m77 Hawkeye Africans ARE CRF, the only Rugers that are not are the 1st model m77s with the tang safety. All mks 2 and Hawkeyes are crf with fixed blade extractors.I’d suggest getting a 375 H&H barrel for the Blaser.
I know it’s going to cost more than the 375 Ruger but it’ll also retain more resale value used. It’ll takedown and pack smaller than a 2nd rifle as well. You’ll have more ammo options with the H&H over the Ruger. The $1000 NIB 375 Rugers also aren’t CRF guns, then again neither is the R8. If Buffalo is your goal then I’d suggest CRF or the Blaser over a PF Bolt Gun. You’re going to struggle to find a decent LH CRF Rifle that’s affordable which brings me back to the R8 being my choice.
You can also hunt everything with either 375 option and might find the 300Wby doesn’t get used until after your buffalo is in the salt.
For left hand 375 ruger the M77 Hawkeye African is probably the best thing (really only) on the market in the $1000 dollar range for a classic wood steel rifle. Like all factory rifles they really do need a quality full glass bedding job. I did this to mine and it shoots 3/4 moa and functions perfectly.