I’ll give you an example from experience. We spotted a nice brown bear on the flats and made a move on him. The wind was in our favor but must have eddied around the point we used for cover and the bear was nose up and walking to the timber at 120 yards when we got into position. My son dropped prone and perfectly placed a heavy for caliber bullet from his .30-06 behind the shoulder. The bear roared, bit the spot, and took off on a dead run for the timber. I dropped to a kneeling position and put a .270 gr A-Frame within 2” of my son’s shot. The boar flipped in the air, landed on his back and twitched one leg, stone dead. He was about ten yards from the timber.
Was my son’s shot fatal? Absolutely. Was it sufficient to keep that boar out of the timber where a follow-up could have gotten sporty? No way.
Another thing to consider on interior vs coastal griz. Interior griz are smaller, but they tend to have a much more disagreeable disposition. A friend was on his porch in Fairbanks when his dogs came out of the bush with an enraged griz on their tail. He had a .45-70 inside the door and dropped that bear just off the porch. I’m sure those dogs had a lot to do with it, but when we lived on the coast, the brownies that wandered through town did not seem to get into it with the local canines.