I have done a lot of research/testing of Barnes bullets and we have taken quite a number of animals. I have load data/testing/chrono results for a number of cartridges.
This is what I have learned:
Use TTSX and not TSX. They start opening sooner and are more reliable for expansion.
Select a lighter bullet as a Barnes bullet acts like a lead core bullet 30% heavier. This is very important.
Barnes bullets like speed and the faster you push them the more accurate they get. See above.
They give better terminal performance when pushed fast---Another reason to select a lighter bullet.
Seat the DEEP. Look at any box or Barnes factory loads and you will see the top relief groove just showing and they usually give excellent accuracy if you do the one other important thing before shooting them. I started measuring distance off the rifling(and having it close) and as I seated the bullet deeper accuracy improved. The deeper seating will also allow for a hotter load without pressure problems. I have a 257W with .250"+ jump and it will put 5-10 shots into one hole when I do my job. Other rifles do not have that much jump but .080"+ is not uncommon for great accuracy.............Start by seating the bullets so the top relief groove is showing and you will probably find no need to change it.
One important thing to do to avoid fouling and often better accuracy is to super clean your barrel. That means not using old #9! I use wipe-out foaming cleaner followed by Sweets 7.62 or Barnes CR-10. Then a finely I use Butches Bore Shine or another good regular cleaner. If you really think #9 does anything use it last. NOW that you have a super clean barrel ONLY shoot Barnes bullets. If I am testing different bullets I shoot the non-Barnes After shooting the Barnes NOT before. Any "fouling shots" need to be Barnes.
Use Barnes data ONLY for Barnes bullets. Sometimes Hodgdons has data for Barnes but be sure it is for TSX or TTSX(Data can be used interchangeably) and not the old X-Bullet or coated bullet. Sometimes Accurate has Barnes data. Barnes has data on their website and the newer manual has TSX/TTSX data. I have also gotten some data from mags and such.
I do not like to waste bullets so I pick the 2-4 powders with the top speeds and just load the max in the Barnes data. Not accepted method but never had a problem. Note some of the Barnes data is over 100% fill and I usually will not try the ones with 103%+ just because it is very hard(even with long drop tubes) to get it all in the case. Also I have spoke with(face to face) the Barnes people about starting at max loads and they told me there room to go above it. I do not do so usually but it shows that the max load is safe to shoot------Especially if you seat the bullets deep.
Follow these simple(but backwards from common wisdom) rules and you will have great ammo that is accurate and really puts down game.
I have data for 257R/25-06/257W/6.5X55/264Win mag/7-08/308win/30-06/300win mag/338win mag. I also have data for the Barnes VG in 204Ruger and 223. All data is over my Chrono and for accuracy........well as good as I can shoot on a given day
If anyone wants data for these cartridges I have Barnes/Swift/Nosler/Hornady data and I have data minus the Barnes for other cartridges. PM me with an email and I can scan it to you.