The 160gr 7mm, 180gr .308, and 270gr .375 have similar sectional densities, one of the aspects to good penetration, of course bullet construction does play a key part. I shoot mostly 180 and 200gr from my 300 Win Mag, and mostly 300gr from my 375 Ruger, right now I have been "plinking" with Hornady 300gr FMJ, they have been on sale at the Hornady website for $25/50, so I bought a couple hundred. So far they have given good accuracy from my rifle, not quite as good as the 300gr Interlock, and about the same as the 300gr DGX blemished bullets that I bought 200 of as well. I sure hope it takes a lot of rounds to shoot out this barrel, because i really love loading for it, and shooting it. Growing up in Oregon, I have seen more elk killed with the 30'06 than any 2 other rounds, friend here in New Mexico killed an elk and an Oryx last week with his 30'06, one shot each, no tracking.