I did a little experimenting with my 300 BLK while I was loading. I reduced my sub-sonic loads by .3 of a grain of powder and was shocked by the results. My average velocity went from 948 fps down to 806 fps. I was not expecting such a dramatic loss of speed. Accuracy also suffered quite a bit. Lesson learned and now I'm going back to 11.5 gr.
While experimenting reload data on my 22 Hornet, and reading various information. I discovered that I needed to adjust the powder charge increments by .1 to find the best powder charge for a given bullet weight.
I thought that's crazy, a .1 grain is an insignificant amount of powder 1 kernel or a couple, three flakes doesn't make a difference. [Since it doesn't make that much difference in larger calibers. ie. 30-30, 30-06, 6.8 SPC, etc, powder charge weight at +/-.2 grains]
That .1 grain makes a lot of difference in that little caliber. In velocities and accuracy. I went up .3 at .1 grain at a time same powder, same powder charge weight, works for both the 45 grain and the 50 grain bullets.
Another tidbit on reloading for MY Ruger model 77 22 Hornet; according the the reloading manuals: Hornady, Speer, Sierra, Lyman, and RCBS. The C.O.A.L. for the 45 grain is the same in all 4 manuals 1.723. The C.O.A.L. for the 50 grain varies: 1.723, 1.740 and 1.750. The C.O.A.L for 55 grain FMJ bullets is 1.780.
Moving both the 45 and 50 grain bullets to a C.O.A.L. of 1.760 to 1.775 also improved the accuracy.