I too am a lefty, welcome to the struggle. No Africa trips planned quite yet, but I've started a savings account for it, bought the rifle and begun to get proficient, and got it signed off by my better half so now its just a matter of time and funds.Congrats on your new rifle. I’m in a similar situation. I bought a Model 70 in 375 about 2 months ago. I enjoy shooting it and it is very accurate. As mentioned earlier, it seems like it will be a gateway for me as well. I am currently looking for a 404 Jeff or a 416 Rem. My issue is I am a lefty and they really limits the options. I did read the Ruger no 1 thread yesterday, so those rifles have my interest now. Sorry to derail your post. You have an Africa trip planned for your new 375?