To me, when encountering dangerous game, a backup needs to be complete and utter overkill. This is entirely just my personal viewpoint, so take it with a grain of salt. A .44 magnum has been prooven against almost every animal out there. However, in my opinion it is just too light to be my safety backup if a buffalo, hippo, or elephant is charging. I happen to be 6'4" and 220lbs. So my backup is going to be my most powerful revolver. The question will be, can a .44 magnum stop any of those 3? The answer, hard maybe. With a buffalo, i'd call it 50%. With a hippo, more than likely your numbers drop to a 20% tops, and with elephant, i'd call it less than 10%. Ive had a .460 Magnum XVR for 15 years now, and it delivers near double the performance of a hot .44 magnum load. Your effective maximum performance from factory ammo with the .44 magnum being a 340gr hard cast delivering 1533ft/lbs of energy (Buffalo Bore +P+ LFN). The .460 Magnum maximum performance from the factory being a 360 gr hard cast delivering 2860ft/lbs of energy. (Buffalo Bore LFN). I handload 360gr hard cast for mine slightly hotter, running 1975fps instead of 1900 resulting in 3,112ft/lbs of energy. (I do see a bit of primer flow in this load, so i only kept em for dangerous game carry which i never used em for and was extremely meticulous in measuring to the 100th of a grain.) Now i have a .500 Bushwhacker that i have 400gr copper solids backed by 85gr of CFE BLK that are going 2526fps for 5,669ft/lbs of energy, that have been prooven to pass through over 100" of ballistic gel. This new revolver will absolutely deliver plenty of performance for any charging animal, if, and thats a really big IF, i can land the shots on target. Right now, i'm still practicing with it, and certainly need to elevate my marksmanship with it. So as of current, i've kept my 360gr handloads on the shelf waiting for either a trip to Africa, or to be shot for entertainment here at home. I know this has been a long read, sorry about the novel.