For buffalo, a 416 Rem Mag or 416 Rigby loaded with 400 grain Barnes TSX or 400 grain Swift A-Frame I think is about perfect. Going back again in 2026 with a different caliber, my Custom BRNO 458 Lott using 500 grain Barnes TSX for buffalo. I’m taking my 458 Lott not because I feel it necessary but for a few reasons: the felt recoil isn’t noticeably more than my 416 Rigby, I can shoot the 458 Lott just as accurately as my 416’s and for sentimental reasons.
Jack Lott himself originally built this rifle for an editor of Petersen’s Hunting but due to unforeseen circumstances it never made it to Africa. AH member Luvthunt graciously sold me this rifle and I shall fulfill it’s destiny by taking it to Africa and killing a buffalo or two and perhaps another DG.
I would feel very comfortable using a good quality bolt action rifle chambered in anything from 375 to 458 Lott with a good low power variable scope, loaded with Barnes TSX or Swift A-Frame. Being proficient with your rifle is more important than the caliber.